Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release while Breastfeeding

Q: My doctor has prescribed me Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release , what should I do?

Though Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.

Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release Breastfeeding

American Academy of Pediatrics and other medical experts exclusively recommend to breastfeed the baby for first 6 months. Once you introduce baby to other foods it is recommended to breastfeed for at least first year of babys life. Taking medication while breastfeeding could be tricky as most drugs pass in breast milk. In this article we will evaluate Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release for its safety in breastfeeding.

What is Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release ?

1 INDICATIONS & USAGE Morphine Sulfate Extended-Release Tablets are indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. Limitations of Use Morphine sulfate extended-release tablets are not for use: As an as-needed (prn) analgesic. For pain that is mild or not expected to persist for an extended period of time For acute pain In the immediate postoperative period (the first 24 hours following surgery) for patients not previously taking the drug, because its safety in this setting has not been established. For postoperative pain unless the patient is already receiving chronic opioid therapy prior to surgery or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time. Morphine sulfate extended-release 100 mg and 200 mg tablets are only for patients in whom tolerance to an opioid of comparable potency is established. Patients considered opioid-tolerant are those taking at least 60 mg of morphine daily, at least 30 mg of oral oxycodone daily, at least 8 mg of oral hydromorphone daily, or an equianalgesic dose of another opioid for a week or longer. Morphine sulfate extended-release tablets are an opioid agonist product indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time. (1) Limitations of Use Morphine sulfate extended-release tablets are not for use: As an as-needed (prn) analgesic (1) For pain that is mild or not expected to persist for an extended period of time (1) For acute pain (1) In the immediate postoperative period (1) For postoperative pain, unless the patient is already receiving chronic opioid therapy prior to surgery, or if the postoperative pain is expected to be moderate to severe and persist for an extended period of time (1) Morphine sulfate extended-release 100 mg and 200 mg tablets are only for patients in whom tolerance to an opioid of comparable potency is established. (1)

Can I use Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release while breastfeeding?

Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release low risk for breastfeeding

Morphine sulfate is the one and only active ingredient present in Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release. Morphine sulfate in itself is a low risk drug for lactation so it is easy to understand that Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release also comes in category of Low Risk item while breastfeeding. Below is the summary of Morphine sulfate in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Morphine is excreted in breast milk, with a milk to plasma morphine AUC ratio of approximately 2.5:1. The amount of morphine received by the infant varies depending on the maternal plasma concentration, the amount of milk ingested by the infant, and the extent of first pass metabolism. Withdrawal signs can occur in breast-feeding infants when maternal administration of morphine is stopped. Because of the potential for adverse reactions in nursing infants from morphine sulfate extended-release tablets, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release Breastfeeding Analsys

Morphine sulfate while Breastfeeding

Low Risk

CAS Number: 57-27-2

Excretion into breast milk is low (even lower when administered through Epidural Anesthesia). In addition, a low oral bioavailability makes that the amount present in the infant's plasma due to absorption from milk by the gut is low. Even though, level of drug has been found in the plasma of infants from treated mothers, harmful effects in the infants were not reported. Levels in the milk are lower and side-effects are fewer among infants whose mothers were treated with Morphine than with Pethidine. Some authorities consider Morphine as the elective opioid medication for breastfeeding mothers. Analgesia used during the birth process is related to a brief delayed of stage II of Lactogenesis (milk come-in). Morphine increases Prolactin level and may decrease Oxytocin level, but it would not be determinant for already established lactations. Avoidance of repetitive or chronic use and follow-up for somnolence and adequacy of infant nourishment is recommended. Bed-sharing should be avoid whenever this medication is used by parents. The American Academy of Pediatrics rates it as compatible with breastfeeding.

Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release Breastfeeding Analsys - 2

Morphine sulfate while Breastfeeding

CAS Number: 57-27-2

Epidural morphine given to mothers for postcesarean section analgesia results in trivial amounts of morphine in their colostrum and milk. Intravenous or oral doses of maternal morphine in the immediate postpartum period result in higher milk levels than with epidural morphine. Labor pain medication may delay the onset of lactation. Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression and even death, although low-dose morphine might be preferred over other opiates.[1] Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of morphine to a 2 to 3 days at a low dosage with close infant monitoring, especially in the outpatient setting.[2] If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately.

I already used Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release and meanwhile I breastfed my baby should I be concerned?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release then you shall inform your doctor, But you should not be worried too much as Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release comes in category of low risk drug.

My doctor has prescribed me Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release, what should I do?

Though Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.

If I am using Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release, will my baby need extra monitoring?

Not much

Who can I talk to if I have questions about usage of Morphine Sulfate Extended Release | Morphine Sulfate Tablet, Film Coated, Extended Release in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week