Mitigo | Morphine Sulfate Injection while Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Mitigo | Morphine Sulfate Injection is safe in breast-feeding or not.

What is Mitigo | Morphine Sulfate Injection used for?


1 INDICATIONS & USAGE MITIGO is for use in continuous microinfusion devices and indicated only for intrathecal or epidural infusion in the management of intractable chronic pain severe enough to require an opioid analgesic and for which less invasive means of controlling pain are inadequate. Limitations of Use Not for single-dose intravenous, intramuscular, or subcutaneous administration due to the risk of overdose. Not for single-dose neuraxial injection because MITIGO is too concentrated for accurate delivery of the smaller doses used in this setting. MITIGO (Morphine Sulfate Injection, USP – Preservative-free) is an opioid agonist, for use in continuous microinfusion devices and indicated only for intrathecal or epidural infusion in the management of intractable chronic pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. ( 1)

Mitigo | Morphine Sulfate Injection while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Mitigo | Morphine Sulfate Injection low risk for breastfeeding
Morphine sulfate is the one and only active ingredient present in Mitigo | Morphine Sulfate Injection. Morphine sulfate in itself is a low risk drug for lactation so it is easy to understand that Mitigo | Morphine Sulfate Injection also comes in category of Low Risk item while breastfeeding. Below is the summary of Morphine sulfate in breastfeeding.

Mitigo | Morphine Sulfate Injection Breastfeeding Analsys


Morphine sulfate while Breastfeeding

Low Risk

CAS Number: 57-27-2

Excretion into breast milk is low (even lower when administered through Epidural Anesthesia). In addition, a low oral bioavailability makes that the amount present in the infant's plasma due to absorption from milk by the gut is low. Even though, level of drug has been found in the plasma of infants from treated mothers, harmful effects in the infants were not reported. Levels in the milk are lower and side-effects are fewer among infants whose mothers were treated with Morphine than with Pethidine. Some authorities consider Morphine as the elective opioid medication for breastfeeding mothers. Analgesia used during the birth process is related to a brief delayed of stage II of Lactogenesis (milk come-in). Morphine increases Prolactin level and may decrease Oxytocin level, but it would not be determinant for already established lactations. Avoidance of repetitive or chronic use and follow-up for somnolence and adequacy of infant nourishment is recommended. Bed-sharing should be avoid whenever this medication is used by parents. The American Academy of Pediatrics rates it as compatible with breastfeeding.


Mitigo | Morphine Sulfate Injection Breastfeeding Analsys - 2


Morphine sulfate while Breastfeeding

CAS Number: 57-27-2

Mitigo | Morphine Sulfate Injection and breastfeeding

Epidural morphine given to mothers for postcesarean section analgesia results in trivial amounts of morphine in their colostrum and milk. Intravenous or oral doses of maternal morphine in the immediate postpartum period result in higher milk levels than with epidural morphine. Labor pain medication may delay the onset of lactation. Maternal use of oral narcotics during breastfeeding can cause infant drowsiness, central nervous system depression and even death, although low-dose morphine might be preferred over other opiates.[1] Newborn infants seem to be particularly sensitive to the effects of even small dosages of narcotic analgesics. Once the mother's milk comes in, it is best to provide pain control with a nonnarcotic analgesic and limit maternal intake of morphine to a 2 to 3 days at a low dosage with close infant monitoring, especially in the outpatient setting.[2] If the baby shows signs of increased sleepiness (more than usual), difficulty breastfeeding, breathing difficulties, or limpness, a physician should be contacted immediately.


Is Mitigo | Morphine Sulfate Injection safe while breastfeeding

I am nursing mother and I have already used Mitigo | Morphine Sulfate Injection, what should I do?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Mitigo | Morphine Sulfate Injection then you shall inform your doctor, But you should not be worried too much as Mitigo | Morphine Sulfate Injection comes in category of low risk drug.


I am nursing mother and my doctor has suggested me to use Mitigo | Morphine Sulfate Injection, is it safe?

Though Mitigo | Morphine Sulfate Injection dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Mitigo | Morphine Sulfate Injection, will my baby need extra monitoring?

Not much


Who can I talk to if I have questions about usage of Mitigo | Morphine Sulfate Injection in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week