Estradiol Tablet while Breastfeeding

Q: I am nursing mother and my doctor has suggested me to use Estradiol Tablet , is it safe?

Though Estradiol Tablet dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.

Q: If I am using Estradiol Tablet , will my baby need extra monitoring?

Not much monitoring required while using Estradiol Tablet

Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Estradiol Tablet is safe in breast-feeding or not.

What is Estradiol Tablet used for?

Estradiol Tablets USP are indicated in the: Treatment of moderate to severe vasomotor symptoms associated with the menopause. Treatment of moderate to severe symptoms of vulvar and vaginal atrophy associated with the menopause. When prescribing solely for the treatment of symptoms of vulvar and vaginal atrophy, topical vaginal products should be considered. Treatment of hypoestrogenism due to hypogonadism, castration or primary ovarian failure. Treatment of breast cancer (for palliation only) in appropriately selected women and men with metastatic disease. Treatment of advanced androgen-dependent carcinoma of the prostate (for palliation only). Prevention of osteoporosis. When prescribing solely for the prevention of postmenopausal osteoporosis, therapy should only be considered for women at significant risk of osteoporosis and for whom non-estrogen medications are not considered to be appropriate. (See CLINICAL PHARMACOLOGY, Clinical Studies.)The mainstays for decreasing the risk of postmenopausal osteoporosis are weight bearing exercise, adequate calcium and vitamin D intake, and when indicated, pharmacologic therapy. Postmenopausal women require an average of 500 mg/day of elemental calcium. Therefore, when not contraindicated, calcium supplementation may be helpful for women with suboptimal dietary intake. Vitamin D supplementation of 400-800 IU/day may also be required to ensure adequate daily intake in postmenopausal women.

Is Estradiol Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Estradiol Tablet low risk for breastfeeding

Estradiol is the one and only active ingredient present in Estradiol Tablet. Estradiol in itself is a low risk drug for lactation so it is easy to understand that Estradiol Tablet also comes in category of Low Risk item while breastfeeding. Below is the summary of Estradiol in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
G. Nursing Mothers Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milk. Detectable amounts of estrogens have been identified in the milk of mothers receiving this drug. Caution should be exercised when estradiol is administered to a nursing woman.

Estradiol Tablet Breastfeeding Analsys

Estradiol while Breastfeeding

Low Risk

CAS Number: 50-28-2

A natural Estrogen that is marketed for oral, injection and topical administration (skin and vaginal).On the chemical form of valerate, it is used in association with a progestin as a combined birth-control compound (e.g. Estradiol + Dienogest) Estradiol is excreted into breast milk in clinically non-significant amount (Nilson 1978) and no problems have been observed in infants whose mothers were treated (Pinheiro 2016). Plasma levels of these infants were undetectable or very low (Pinheiro 2016). After administration in the form of transdermal patches milk levels have been undetectable (Pinheiro 2016, Perheentupa 2004). Despite these data, an older publication associated the use of transdermal estradiol with a case of jaundice and poor weight gain (Ball 1999).There is greater passage to milk when the administration is vaginal. There is evidence (albeit inconsistent) that estrogen-containing pills may decrease milk production, especially during the first few weeks postpartumThey may reduce the protein content of the milk. No problems have been observed in infants whose mothers were treated, except some cases of transient gynecomastia in infants whose mothers were receiving a higher dose than usual. Estrogen exposure in childhood or adolescence, does not influence the subsequent production of milk. The American Academy of Pediatrics states that this medication is usually compatible with breastfeeding.

Estradiol Tablet Breastfeeding Analsys - 2

Estradiol while Breastfeeding

CAS Number: 50-28-2

Is Estradiol Tablet safe while breastfeeding

Limited information on the use of estradiol during breastfeeding indicates that the route of administration and dosage form have influences on the amount transferred into breastmilk. Vaginal administration results in measurable amounts in milk, but transdermal patches do not. Maternal doses of up to 200 mcg daily transdermally do not increase estradiol or estriol in breastfed infants or cause any adverse effects in breastfed infants. Vaginal administration results in unpredictable peak times for estradiol in breastmilk, so timing of the dose with respect to breastfeeding is probably not useful. A case report of inadequate milk production and inadequate infant weight gain was possibly caused by transdermal estradiol initiated on the first day postpartum, but 2 small studies found no such effect when the drug was initiated after lactation was well established.

I am nursing mother and I have already used Estradiol Tablet, what should I do?

Estradiol Tablet is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Estradiol Tablet so you should inform him based on your convenience.

I am nursing mother and my doctor has suggested me to use Estradiol Tablet, is it safe?

Though Estradiol Tablet dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.

If I am using Estradiol Tablet, will my baby need extra monitoring?

Not much monitoring required while using Estradiol Tablet

Who can I talk to if I have questions about usage of Estradiol Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

What is Estradiol Tablet used for?

Is Estradiol Tablet usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Estradiol while Breastfeeding

Estradiol while Breastfeeding

I am nursing mother and I have already used Estradiol Tablet, what should I do?

I am nursing mother and my doctor has suggested me to use Estradiol Tablet, is it safe?

If I am using Estradiol Tablet, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Estradiol Tablet in breastfeeding?

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