Medroxyprogesterone Acetate Injection, Suspension Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Medroxyprogesterone Acetate Injection, Suspension is safe in breast-feeding or not.

What is Medroxyprogesterone Acetate Injection, Suspension used for?


Medroxyprogesterone Acetate Injectable Suspension, USP is indicated only for the prevention of pregnancy. The loss of bone mineral density (BMD) in women of all ages and the impact on peak bone mass in adolescents should be considered, along with the decrease in BMD that occurs during pregnancy and/or lactation, in the risk/benefit assessment for women who use Medroxyprogesterone Acetate Injectable Suspension, USP long-term (see WARNINGS.) It is a long-term injectable contraceptive in women when administered at 3-month (13-week) intervals. Dosage does not need to be adjusted for body weight. In five clinical studies using Medroxyprogesterone Acetate Injectable Suspension, USP, the 12-month failure rate for the group of women treated with Medroxyprogesterone Acetate Injectable Suspension, USP was zero (no pregnancies reported) to 0.7 by Life-Table method. Pregnancy rates with contraceptive measures are typically reported for only the first year of use as shown in Table 1. Except for intrauterine devices (IUD), implants, sterilization, and Medroxyprogesterone Acetate Injectable Suspension, USP, the efficacy of these contraceptive measures depends in part on the reliability of use. The effectiveness of Medroxyprogesterone Acetate Injectable Suspension, USP is dependent on the patient returning every 3 months (13 weeks) for reinjection. Table 1 Lowest Expected and Typical Failure RatesLowest expected - when used exactly as directed. Typical - includes those not following directions exactly. Expressed as Percent of Women Experiencing an Accidental Pregnancy in the First Year of Continuous Use Method Lowest Expected Typical Source: Trussell et al1 Injectable progestogen Medroxyprogesterone 0.3 0.3 Acetate Implants Norplant (6 capsules) 0.2from Norplant® package insert. 0.2 Female sterilization 0.2 0.4 Male sterilization 0.1 0.15 Pill 3 Combined 0.1 Progestogen only 0.5 IUD 3 Progestasert 2 Copper T 380A 0.8 Condom 2 12 Diaphragm 6 18 Cap 6 18 Spermicides 3 21 Sponge Parous women 9 28 Nulliparous women 6 18 Periodic abstinence 1–9 20 Withdrawal 4 18 No method 85 85

Is using Medroxyprogesterone Acetate Injection, Suspension unsafe in breastfeeding? Can there be bad consequences for baby if I use it while breastfeeding?

Medroxyprogesterone Acetate Injection, Suspension safe for breastfeeding
As per our analysis Medroxyprogesterone Acetate Injection, Suspension contains only one ingredient and that is Medroxyprogesterone. We have analyzed Medroxyprogesterone and it seems to be safe to use Medroxyprogesterone while breastfeeding, that means usage of Medroxyprogesterone Acetate Injection, Suspension shall be safe while breastfeeding. Below you can check more details of Medroxyprogesterone usage in breastfeeding. We recommend you to go through provided detailed analysis as below take decision accordingly.

Statement of Manufacturer/Labeler about breastfeeding usage
NURSING MOTHERS See "WARNINGS" section 8.

Medroxyprogesterone Acetate Injection, Suspension Breastfeeding Analsys


Medroxyprogesterone while Breastfeeding

Safe

CAS Number: 71-58-9

Synthetic progestin similar to progesterone that is used in uterine bleeding, dysmenorrhea, infertility and contraception.For contraception is used as a single drug or in combination with estrogen (e.g. Estradiol + Medroxyprogesterone).For oral use or long-acting injectable administration (Intramuscular or subcutaneous). It is excreted into breast milk in clinically non-significant amount, and, no problems have been observed in infants whose mothers who were treated with this medication. Plasma levels of these infants were undetectable or very low.There may be increased prolactin and milk production in women who receive medroxyprogesterone. Although it has not been shown effects on production and duration of breastfeeding when administered at any time postpartum, it is still controversial on if it really decreases milk production when progestins are used before a fully establishment of breastfeeding has occurred. Therefore, experts’ protocols by WHO and ABM advise to avoiding it until breastfeeding is fully developed (4-6 weeks). During lactation progestin-only drugs are preferred or in combination with estrogen for birth control, but whatever, the ones with the lower doses of estrogen should be used.For the first 6 weeks postpartum, non-hormonal methods are of choise. Hormone containing contraceptives do not affect the composition of milk, minerals (Mg, Fe, Cu, Ca, P) fat, lactose and calories but only a few the proteins. WHO List of Essential Medicines 2002: rates it as compatible with breastfeeding after the 6th postnatal week.


Medroxyprogesterone Acetate Injection, Suspension Breastfeeding Analsys - 2


Medroxyprogesterone while Breastfeeding

CAS Number: 71-58-9

Although nonhormonal methods are preferred during breastfeeding, progestin-only contraceptives such as depot medroxyprogesterone acetate (DMPA) are considered the hormonal contraceptives of choice during all stages of lactation. Fair quality evidence indicates that DMPA does not adversely affect the composition of milk, the growth and development of the infant, or the milk supply.[1][2][3][4] Some evidence indicates that progestin-only contraceptives may offer protection against bone mineral density loss during lactation, or at least do not exacerbate it.[5][6][7] The timing of initiation of DMPA is controversial.[8] The product labeling states that it should be started no sooner than 6 weeks postpartum, based on data submitted for product approval. Studies of fair quality seem to indicate that concerns about immediate adverse effects on the infants is unfounded; however, starting too soon theoretically could affect the newborn infant adversely because of slower metabolism of the drug than older infants. Of concern is that no data exist on the effects of progesterone on brain and liver development at this age. Administration sooner than 6 weeks postpartum could interfere with the exclusivity or duration of lactation. A systematic review of studies using early postpartum initiation of DMPA concluded that all of the studies were of low quality and inadequate to disprove the concern about DMPA's effects on milk production if given sooner than 6 weeks after delivery.[9] A subsequent study raised the possibility of a slight reduction in breastfeeding duration in women given DMPA before hospital discharge,[10] and another study found that breastfeeding was less like to be initiated if mothers received immediate postpartum DMPA.[11] Expert opinion in the United States holds that the risks of progestin-only contraceptive products usually are acceptable for nursing mothers at any time postpartum.[12]The World Health Organization recommends that injectable depot medroxyprogesterone acetate should not used before 6 weeks postpartum.[13]



I am nursing mother and I have already used Medroxyprogesterone Acetate Injection, Suspension, what should I do?

It is always a good idea to keep your healthcare provider or doctor informed about your drug usage during pregnancy and breastfeeding but if you have not informed your doctor about Medroxyprogesterone Acetate Injection, Suspension and have used it then do not panic as Medroxyprogesterone Acetate Injection, Suspension is mostly safe in breastfeeding and should not cause any harm to your baby.


My health care provider has asked me to use Medroxyprogesterone Acetate Injection, Suspension, what to do?

Definitely, Medroxyprogesterone Acetate Injection, Suspension is safe in lactation for baby. No wonder your doctor has recommended it.


If I am using Medroxyprogesterone Acetate Injection, Suspension, will my baby need extra monitoring?

No extra baby monitoring required while mother is using Medroxyprogesterone Acetate Injection, Suspension


Who can I talk to if I have questions about usage of Medroxyprogesterone Acetate Injection, Suspension in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week