Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops while Breastfeeding
Modern medicine has evolved so much so that sooner or later every breastfeeding mother needs to take it in one form or other. Medication that is present in mothers blood will transfer into her breast milk to some extent. Most drugs do so at low levels and pose no real risk to infants but then there are some exceptions. In This post will discuss whether Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops is safe in breast-feeding or not.

What is Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops ?


COSOPT® PF is indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time). The IOP-lowering of COSOPT® administered twice a day was slightly less than that seen with the concomitant administration of 0.5% timolol administered twice a day and 2% dorzolamide administered three times a day [see Clinical Studies (14.1)]. COSOPT PF is a carbonic anhydrase inhibitor with a beta-adrenergic receptor blocking agent indicated for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers. The IOP-lowering of COSOPT twice daily was slightly less than that seen with the concomitant administration of 0.5% timolol twice daily, and 2% dorzolamide three times daily. (1)

Is using Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops safe or dangerous while breastfeeding?

Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops low risk for breastfeeding
Dorzolamide and Timolol anhydrous are the two main ingredients of Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops. Based on our individual analysis of Dorzolamide and Timolol anhydrous we can safely say that Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops has low risk while breastfeeding. Below we have summarized the usage of Dorzolamide and Timolol anhydrous while breastfeeding, we recommend you to go through it for better understanding of your usage.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers It is not known whether dorzolamide is excreted in human milk. Timolol maleate has been detected in human milk following oral and ophthalmic drug administration. Because of the potential for serious adverse reactions from COSOPT PF in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops Breastfeeding Analsys


Dorzolamide while Breastfeeding

Low Risk

It inhibits activity of carbonic anhydrase.Systemic absorption is minimal. There have not been problems except when a maternal overdose was absorbed. Like most ophthalmologic compounds for topical use a low dose and poor absorption make it compatible with breastfeeding. No untoward effect has been described.

Timolol anhydrous while Breastfeeding

Safe

CAS Number: 26839-75-8

It is used as hypotensive drug, and, on topical treatment of glaucoma. Systemic absorption is minimal. There have not been problems except when a maternal overdose has been absorbed. Like most ophthalmologic compounds for topical use a low dose and poor absorption make it compatible with breastfeeding.

Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops Breastfeeding Analsys - 2


Dorzolamide while Breastfeeding

CAS Number: 120279-96-1

Limited experience with the use of ophthalmic dorzolamide indicate that it is unlikely to adversely affect the breastfed infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Timolol anhydrous while Breastfeeding

CAS Number: 26839-75-8

Is Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops safe while breastfeeding

Because of the variability in excretion of timolol into breastmilk and minimal reported experience during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.Ophthalmic use of timolol by the mother should pose little risk to the breastfed infant. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops safe for breastfeeding

I am nursing mother and I have already used Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops, what should I do?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops then you shall inform your doctor, But you should not be worried too much as Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops comes in category of low risk drug.


My doctor has prescribed me Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops, what should I do?

Though Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops, will my baby need extra monitoring?

Not much


Who can I talk to if I have questions about usage of Cosopt Pf | Dorzolamide Hydrochloride And Timolol Maleate Solution/ Drops in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

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