Zoledronic Acid Injection while Breastfeeding
Most health expert recommend six month of exclusive breastfeeding but statics suggest that numbers are not good, almost 95% mothers start breastfeeding but this number drops to 40% in first three month and further it drops to 15% till fifth month. Sometime its due to need of medication usage. Because of these statics its important to provide good information on safety of drugs in breastfeeding so that it can be improved when possible. In this FAQ sheet we will discuss about exposure to Zoledronic Acid Injection while breastfeeding. We will also discuss about common side effects and warnings associated with Zoledronic Acid Injection.

What is Zoledronic Acid Injection used for?


1. INDICATIONS AND USAGE Zoledronic acid injection is a bisphosphonate indicated for: • Treatment of Paget's disease of bone in men and women (1.5) 1.5 Paget's Disease of Bone Zoledronic acid injection is indicated for treatment of Paget's disease of bone in men and women. Treatment is indicated in patients with Paget's disease of bone with elevations in serum alkaline phosphatase of two times or higher than the upper limit of the age-specific normal reference range, or those who are symptomatic, or those at risk for complications from their disease [see Clinical Studies (14.5) ].

I am breastfeeding mother and I am using Zoledronic Acid Injection. Can it have any bad effect on my kid? Shall I search for better alternative?

Zoledronic Acid Injection low risk for breastfeeding
Zoledronic acid anhydrous is the one and only active ingredient present in Zoledronic Acid Injection. Zoledronic acid anhydrous in itself is a low risk drug for lactation so it is easy to understand that Zoledronic Acid Injection also comes in category of Low Risk item while breastfeeding. Below is the summary of Zoledronic acid anhydrous in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers It is not known whether zoledronic acid is excreted in human milk. Because many drugs are excreted in human milk, and because zoledronic acid binds to bone long-term, zoledronic acid injection should not be administered to a nursing woman.

Zoledronic Acid Injection Breastfeeding Analsys


Zoledronic acid anhydrous while Breastfeeding

Low Risk

CAS Number: 118072-93-8

It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Among bisphosponate preparations, Tiludronate and Zoledronate have the longest half-lives period of elimination and thus they are the less indicated to take while breastfeeding. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.

Zoledronic Acid Injection Breastfeeding Analsys - 2


Zoledronic acid anhydrous while Breastfeeding

CAS Number: 118072-93-8

Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely.


What should I do if already breastfed my kid after using Zoledronic Acid Injection?

Zoledronic Acid Injection is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Zoledronic Acid Injection so you should inform him based on your convenience.


I am nursing mother and my doctor has suggested me to use Zoledronic Acid Injection, is it safe?

Zoledronic Acid Injection comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.


If I am using Zoledronic Acid Injection, will my baby need extra monitoring?

Not much monitoring required while using Zoledronic Acid Injection


Who can I talk to if I have questions about usage of Zoledronic Acid Injection in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

Drug Brands with same Active ingredients

Zoledronic Acid Injection, Solution, Concentrate
Zoledronic Acid Solution
Zometa | Zoledronic Acid Injection, Solution, Concentrate
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