Zoledronic Acid Injection, Solution, Concentrate Breastfeeding

It is recommended to breastfeed exclusively for six months and then while introducing to other food sources extend it to twelve months. In this duration most mothers will need help of some sort of medication, It could be for short term like could and flue or it could be something chronic like Arthritis or Diabetes and here comes the question of safety of medication in use. In this post we will figure out what is Zoledronic Acid Injection, Solution, Concentrate and whether its safe to use Zoledronic Acid Injection, Solution, Concentrate while nursing or not.

What is Zoledronic Acid Injection, Solution, Concentrate used for?


Zoledronic acid Injection is a bisphosphonate indicated for the treatment of: Hypercalcemia of malignancy. (1.1) Patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy. (1.2) Limitations of use: The safety and efficacy of Zoledronic acid Injection has not been established for use in hyperparathyroidism or non-tumor-related hypercalcemia. (1.3) 1.1 Hypercalcemia of Malignancy Zoledronic acid Injection is indicated for the treatment of hypercalcemia of malignancy defined as an albumin-corrected calcium (cCa) of greater than or equal to 12 mg/dL [3.0 mmol/L] using the formula: cCa in mg/dL =Ca in mg/dL + 0.8 ( 4.0 g/dL – patient albumin [g/dL]). 1.2 Multiple Myeloma and Bone Metastases of Solid Tumors Zoledronic acid Injection is indicated for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. Prostate cancer should have progressed after treatment with at least one hormonal therapy. Limitations of Use The safety and efficacy of Zoledronic acid Injection in the treatment of hypercalcemia associated with hyperparathyroidism or with other nontumor-related conditions have not been established.

Is using Zoledronic Acid Injection, Solution, Concentrate unsafe in breastfeeding? Can there be bad consequences for baby if I use it while breastfeeding?

Zoledronic Acid Injection, Solution, Concentrate low risk for breastfeeding
Zoledronic acid anhydrous is the one and only active ingredient present in Zoledronic Acid Injection, Solution, Concentrate. Zoledronic acid anhydrous in itself is a low risk drug for lactation so it is easy to understand that Zoledronic Acid Injection, Solution, Concentrate also comes in category of Low Risk item while breastfeeding. Below is the summary of Zoledronic acid anhydrous in breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers It is not known whether Zoledronic acid is excreted in human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from Zoledronic acid Injection, a decision should be made to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Zoledronic acid binds to bone long term and may be released over weeks to years.

Zoledronic Acid Injection, Solution, Concentrate Breastfeeding Analsys


Zoledronic acid anhydrous while Breastfeeding

Low Risk

CAS Number: 118072-93-8

It is composed by bisphosphonates. Most bisphosphonates are acidic compounds that achieve low plasma concentration. Both features make it unlikely excretion into the milk in clinically significant amount. Intestinal absorption of bisphosphonates is very low even during fasting and is considered negligible in the presence of milk due to formation with the calcium of non absorbable compounds. Among bisphosponate preparations, Tiludronate and Zoledronate have the longest half-lives period of elimination and thus they are the less indicated to take while breastfeeding. A latest update no published data were found on excretion in the breast milk. Until more data about this drug regarding breastfeeding is available, safer known alternatives (pamidronate) should be of choice, especially in the neonatal period and in case of prematurity.

Zoledronic Acid Injection, Solution, Concentrate Breastfeeding Analsys - 2


Zoledronic acid anhydrous while Breastfeeding

CAS Number: 118072-93-8

Because no information is available on the use of zoledronic acid during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of zoledronic acid by a breastfed infant is unlikely.

Is Zoledronic Acid Injection, Solution, Concentrate safe while breastfeeding

What if I already have used Zoledronic Acid Injection, Solution, Concentrate?

Zoledronic Acid Injection, Solution, Concentrate is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Zoledronic Acid Injection, Solution, Concentrate so you should inform him based on your convenience.


My health care provider has asked me to use Zoledronic Acid Injection, Solution, Concentrate, what to do?

Zoledronic Acid Injection, Solution, Concentrate comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.


If I am using Zoledronic Acid Injection, Solution, Concentrate, will my baby need extra monitoring?

Not much monitoring required while using Zoledronic Acid Injection, Solution, Concentrate


Who can I talk to if I have questions about usage of Zoledronic Acid Injection, Solution, Concentrate in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

Drug Brands with same Active ingredients

Zoledronic Acid Solution
Zometa | Zoledronic Acid Injection, Solution, Concentrate
Reclast | Zoledronic Acid Injection