Hepagam B | Hepatitis B Immune Globulin (human) Solution while Breastfeeding
Do you know that important immune protective proteins are present in breast milk? Breast milk also contains required vitamins, minerals, saturated and un saturated fats. These things are extremely important for development of healthy brain. If you are taking any medicine for short term or for the chronic reason then that passes in breast milk as well, that is why you should always check the drug with your health care provider. Here at DrLact we try to analyze drugs based on available researches and in this sheet we will present our analysis for Hepagam B | Hepatitis B Immune Globulin (human) Solution.

What is Hepagam B | Hepatitis B Immune Globulin (human) Solution used for?


HepaGam B [Hepatitis B immune globulin intravenous (Human)] is an intravenous immune globulin indicated for the following: For Intravenous or Intramuscular Administration Only Prevention of Hepatitis B recurrence following Liver Transplantation in HBsAg-positive liver transplant patients (1.1). Postexposure Prophylaxis (1.2) in the following settings: Acute Exposure to Blood Containing HBsAg Perinatal Exposure of Infants Born to HBsAg-positive Mothers Sexual Exposure to HBsAg-positive Persons Household Exposure to Persons with Acute HBV Infection 1.1 Prevention of Hepatitis B recurrence following liver transplant in HBsAg-positive liver transplant patients 1.2 Post-exposure prophylaxis including acute exposure to HBsAg-positive blood, plasma, or serum (parenteral exposure, direct mucus membrane contact, oral ingestion, etc), perinatal exposure of infants born to HBsAg-positive mothers, sexual exposure to HBsAg-positive persons, and household exposure to persons with acute HBV infection.

Is Hepagam B | Hepatitis B Immune Globulin (human) Solution safe to use while breastfeeding? Can it interfere with growth and development of my kid?

Hepagam B | Hepatitis B Immune Globulin (human) Solution safe for breastfeeding
Active ingredient in Hepagam B | Hepatitis B Immune Globulin (human) Solution is Human hepatitis b virus immune globulin and based on our analysis of Human hepatitis b virus immune globulin it appears that using Hepagam B | Hepatitis B Immune Globulin (human) Solution is safe in breastfeeding. Below is analysis of Human hepatitis b virus immune globulin while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers It is not known whether HepaGam B is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when HepaGam B is administered to a nursing mother.

Hepagam B | Hepatitis B Immune Globulin (human) Solution Breastfeeding Analsys


Human hepatitis b virus immune globulin while Breastfeeding

Safe

The secretion of immunoglobulin into breast milk may help to transfer passive immunitation to the child.

Hepagam B | Hepatitis B Immune Globulin (human) Solution Breastfeeding Analsys - 2


Human hepatitis b virus immune globulin while Breastfeeding

CAS Number: 373609-41-7

Hepagam B | Hepatitis B Immune Globulin (human) Solution and breastfeeding

Hepatitis B immune globulin is an immune globulin (IgG) rich in IgG antibodies against hepatis B. IgG is a normal component of breastmilk. No special precautions are required during breastfeeding. Hepatitis B immune globulin is recommended along with hepatitis B vaccine to be given to infants of mothers who are positive for hepatitis B surface antigen. No differences exist in infection rates between breast-fed and formula-fed infants born to hepatitis B-infected women, as long as the infant receives these preventative measures at birth. Mothers with hepatitis B are encouraged to breastfeed their infants after their infants receive these preventative measures.[1][2] Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[3][4] Higher temperatures of 72 and 85 degrees C appear to cause greater loss, but further lyophylization does not cause marked additional loss.[5] A flash heating pasteurization reduced the concentration of endogenous immunoglobulin G by 33%.[6] A continuous flow, high-temperature short-time (HTST) pasteurizer at temperatures ranging from 71 to 74 degrees C retained from about 38 to 79% of IgG activity depending on the temperature and exposure time.[7] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Immunoreactivity against ovalbumin decreased by 4 to 18% and immunoreactivity against tetanus toxoid decreased by 8 to 20%. Specific IgG subclasses decreased by different amounts, with IgG4 retaining all of its activity and IgG1 and 2 decreasing by about 40 to 50%.[8]

Is Hepagam B | Hepatitis B Immune Globulin (human) Solution safe while breastfeeding

I already used Hepagam B | Hepatitis B Immune Globulin (human) Solution and meanwhile I breastfed my baby should I be concerned?

As usage of Hepagam B | Hepatitis B Immune Globulin (human) Solution is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Hepagam B | Hepatitis B Immune Globulin (human) Solution else no further action is required.


My health care provider has asked me to use Hepagam B | Hepatitis B Immune Globulin (human) Solution, what to do?

Usage of Hepagam B | Hepatitis B Immune Globulin (human) Solution is safe for nursing mothers and baby, No worries.


If I am using Hepagam B | Hepatitis B Immune Globulin (human) Solution, will my baby need extra monitoring?

No


Who can I talk to if I have questions about usage of Hepagam B | Hepatitis B Immune Globulin (human) Solution in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

Drug Brands with same Active ingredients

Nabi-hb | Human Hepatitis B Virus Immune Globulin Injection