Pentasa | Mesalamine Capsule while Breastfeeding
What is Pentasa | Mesalamine Capsule used for?
I am breastfeeding mother and I am using Pentasa | Mesalamine Capsule. Can it have any bad effect on my kid? Shall I search for better alternative?
Nursing Mothers Minute quantities of mesalamine were distributed to breast milk and amniotic fluid of pregnant women following sulfasalazine therapy. When treated with sulfasalazine at a dose equivalent to 1.25 g/day of mesalamine, 0.02 μg/mL to 0.08 μg/mL and trace amounts of mesalamine were measured in amniotic fluid and breast milk, respectively. N-acetylmesalamine, in quantities of 0.07 μg/mL to 0.77 μg/mL and 1.13 μg/mL to 3.44 μg/mL, was identified in the same fluids, respectively. Caution should be exercised when PENTASA is administered to a nursing woman. No controlled studies with PENTASA during breast-feeding have been carried out. Hypersensitivity reactions like diarrhea in the infant cannot be excluded.
Pentasa | Mesalamine Capsule Breastfeeding Analsys
Mesalamine while Breastfeeding
SafeCAS Number: 89-57-6
Mesalazine is badly absorbed by the intestine, serum levels are low with scant excretion into breast milk. N-acetyl-5-ASA is an inactive metabolite which is excreted into breast milk but not higher than 10% of relative infant's dose. No harm effects among breastfed infants from treated mothers have been reported, except for rare cases of diarrhea reported in the 80's with the use of Mesalazine compounds different to Balsalazide. In a review of 121 cases and 121 controls, the authors failed to observe those findings. (Moretti, 1989). Expert consensus supports the compatibility of Mesalazine during breastfeeding.
Pentasa | Mesalamine Capsule Breastfeeding Analsys - 2
Mesalamine while Breastfeeding
CAS Number: 89-57-6
Mesalamine is poorly excreted into breastmilk. However, rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. A few cases of diarrhea have been reported in infants exposed to mesalamine, although the rate is not high. Most experts consider mesalamine derivatives to be safe during breastfeeding.[1][2][3][4] If mesalamine is required by the mother, it is not a reason to discontinue breastfeeding, but carefully observe breastfed infants for diarrhea during maternal use of mesalamine.
I already used Pentasa | Mesalamine Capsule and meanwhile I breastfed my baby should I be concerned?
Pentasa | Mesalamine Capsule is safe in breastfeeding and should not create any health problem for your baby but in case you feel any health issue associated with Pentasa | Mesalamine Capsule you should contact your doctor or health care provider. Be it pregnancy or lactation you shall keep your doctor informed.
I am nursing mother and my doctor has suggested me to use Pentasa | Mesalamine Capsule, is it safe?
Definitely, Pentasa | Mesalamine Capsule is safe in lactation for baby. No wonder your doctor has recommended it.
If I am using Pentasa | Mesalamine Capsule, will my baby need extra monitoring?
No extra baby monitoring required while mother is using Pentasa | Mesalamine Capsule
Who can I talk to if I have questions about usage of Pentasa | Mesalamine Capsule in breastfeeding?
US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week