Mesalamine Enema while Breastfeeding

What is Mesalamine Enema used for?

Is Mesalamine Enema usage safe while breastfeeding? If a lactating mother is using it can there be any effect on growth or development of infant?

Mesalamine while Breastfeeding

CAS Number: 89-57-6

Mesalazine is badly absorbed by the intestine, serum levels are low with scant excretion into breast milk. N-acetyl-5-ASA is an inactive metabolite which is excreted into breast milk but not higher than 10% of relative infant's dose. No harm effects among breastfed infants from treated mothers have been reported, except for rare cases of diarrhea reported in the 80's with the use of Mesalazine compounds different to Balsalazide. In a review of 121 cases and 121 controls, the authors failed to observe those findings. (Moretti, 1989). Expert consensus supports the compatibility of Mesalazine during breastfeeding.

Mesalamine while Breastfeeding

CAS Number: 89-57-6

Mesalamine is poorly excreted into breastmilk. However, rather high levels of the mesalamine metabolite N-acetyl-5-ASA appear in breastmilk and its effects on breastfed infants are unknown. A few cases of diarrhea have been reported in infants exposed to mesalamine, although the rate is not high. Most experts consider mesalamine derivatives to be safe during breastfeeding.[1][2][3][4] If mesalamine is required by the mother, it is not a reason to discontinue breastfeeding, but carefully observe breastfed infants for diarrhea during maternal use of mesalamine.

What if I already have used Mesalamine Enema?

I am nursing mother and my doctor has suggested me to use Mesalamine Enema, is it safe?

If I am using Mesalamine Enema, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Mesalamine Enema in breastfeeding?