Xyrem | Sodium Oxybate Solution while Breastfeeding
It is a well known fact that breastfeeding is best source of nutrition for infants. Breast milk provides minerals, vitamins and antibodies in most acceptable format when they need it. Nutrition taken by mother passes to breast-milk and same thing applies to medicines taken by mothers. Not all drugs cause problem for baby but some do. Lets analyze if Xyrem | Sodium Oxybate Solution is safe for baby while breastfed.

What is Xyrem | Sodium Oxybate Solution used for?


Xyrem is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. Xyrem is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy (1).

Xyrem | Sodium Oxybate Solution while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Xyrem | Sodium Oxybate Solution low risk for breastfeeding
Xyrem | Sodium Oxybate Solution contains only one active ingredient that is Sodium oxybate. We have analyzed the usage of Sodium oxybate in breastfeeding and our analysis suggest that Sodium oxybate poses Low risk for infant while breastfeeding and hence Xyrem | Sodium Oxybate Solution itself shall be considered Low risk item for breastfeeding.

Xyrem | Sodium Oxybate Solution Breastfeeding Analsys


Sodium oxybate while Breastfeeding

Low Risk

CAS Number: 502-85-2

Sodium salt of gamma-hydroxybutyric acid (GHBA), a natural body substance normally found in milk at levels of 0.1 - 1 mg / L.It is used for the treatment of narcolepsy. Given its rapid half-life, after 4 to 5 hours the GHBA levels in milk are back in the normal range.Since it is administered in two evening doses at the beginning of the night (22:00 h and 02:00 h) breastfeeding is allowed even exclusively, taking care to wait 4 hours after the last dose. It would be advisable to pump breast milk during the day for using it at night time.The intestinal drug absorption and plasma levels decrease significantly (up 58%) with simultaneous administration of a meal, especially if it has a high fat content. They have not been observed problems in infants whose mothers were on this treatment. At least, one infant was exclusively breastfed for 6 months while her mother was taking sodium oxybate, fluoxetine and cetirizine with a pausing of 4 hours after each of the two doses of oxybate. Oxybate does not alter prolactin levels. See below the information of these related products:

Xyrem | Sodium Oxybate Solution Breastfeeding Analsys - 2


Sodium oxybate while Breastfeeding

CAS Number: 502-85-2 591-81-1

Sodium oxybate is the sodium salt of gamma-hydroxybutyric acid (GHB). GHB is an endogenous substance and low amounts are normally found in breastmilk. Large doses of GHB have been used as a substance of abuse. Infants have been successfully breastfed by mothers taking sodium oxybate therapeutically for narcolepsy. With the typical 2 doses per night treatment regimen, nursing should usually be withheld from the time of the first dose to 4 to 6 hours after the second dose and breastfeeding can be continued during the day.[1] No information is available on the use or safety of GHB as a drug of abuse during breastfeeding.


What should I do if already breastfed my kid after using Xyrem | Sodium Oxybate Solution?

During whole lactation period you shall first discuss with your doctor and then together you shall decide whether you shall take that drug or not however if you have already taken Xyrem | Sodium Oxybate Solution then you shall inform your doctor, But you should not be worried too much as Xyrem | Sodium Oxybate Solution comes in category of low risk drug.


I am nursing mother and my doctor has suggested me to use Xyrem | Sodium Oxybate Solution, is it safe?

Though Xyrem | Sodium Oxybate Solution dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Xyrem | Sodium Oxybate Solution, will my baby need extra monitoring?

Not much


Who can I talk to if I have questions about usage of Xyrem | Sodium Oxybate Solution in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week