Cycloset | Bromocriptine Mesylate Tablet while Breastfeeding

What is Cycloset | Bromocriptine Mesylate Tablet used for?

What are the risk associated with Cycloset | Bromocriptine Mesylate Tablet usage while breastfeeding? What precautions shall I take while using it in breastfeeding?

Bromocriptine while Breastfeeding

CAS Number: 22260-51-1

An ergot derivative alkaloid which is a prolactin inhibitor with dopaminergic activity, indicated for the treatment of prolactinomas and Parkinson's disease.Inhibits milk production by lowering prolactin level (Eglash 2014). Severe and frequent side effects, that are even increased in the postpartum, are: hypertension, seizures, stroke, myocardial infarction and psychiatric disorders (Hopp 1996, Iffy 1996, Kirsch 2001, Bernard 2015, Seeman 2015, Fedrizzi 2015, Snellen 2016) and thereof the indication to suppress lactation has been questioned by medical societies (Oladapo 2009-2012 Marcellin 2015, Sénat 2016) withdrawn in many countries (Nguyen 2015), switching to cabergoline has been proposed (Eglash 2014) along with non-pharmacological measures (Wong 1985 , Prescrire Int. 2013) Pharmacokinetic data (moderately high molecular weight and high binding capacity to plasma proteins) explain the observed almost zero excretion into breastmilk (Peters 1985) or below detection limits (<0.2 micrograms / L).In addition, a low oral bioavailability makes insignificant its absorption from breastmilk to the infant’s plasma. A successful breastfeeding has been described on about 30 cases of galactorrhea-prolactinoma-hyperprolactinemia that were treated with a daily dose of 2.5 to 5 mg of Bromocriptine with no effects noticed on the infants (Canales 1981, Cheng 1996, Verma 2006). Nor side effects occurred on 14 infants whose mothers received 2.5 mg of bromocriptine from 5th to 8th day after birth to treat an alleged galactorrhea (Peters 1985). The risk on breastfeeding would be due to its ability for suppression of milk production, but not to a possible effect on the infant which is considered very unlikely. If Bromocriptine was eventually administered to suppress lactation but afterwards the mother is willing to resuming breastfeeding, the mother can do it immediately, trying to minimize the drug effect by frequent suckling the child to stimulate milk production.

Bromocriptine while Breastfeeding

CAS Number: 25614-03-3

Bromocriptine is usually not used during breastfeeding because it suppresses lactation. The indication of lactation suppression has been withdrawn in the U.S. and discouraged in other countries because it increases the risk of maternal stroke, seizures, cardiovascular disorders, death and possibly psychosis.[1][2][3][4] A low dose of 2.5 mg once daily has been used for 3 days to decrease overproduction of milk. The drug was undetectable in milk with this dosage and infants had no adverse reactions, but the safety of this use is not established. Case reports and series also exist of mothers treated with bromocriptine for amenorrhea-galactorrhea syndrome or prolactinoma during pregnancy and lactation who successfully breastfed their infants. Bromocriptine has been used to treat persistent galactorrhea following breast augmentation surgery.[5]

I already used Cycloset | Bromocriptine Mesylate Tablet and meanwhile I breastfed my baby should I be concerned?

I am nursing mother and my doctor has suggested me to use Cycloset | Bromocriptine Mesylate Tablet, is it safe?

If I am using Cycloset | Bromocriptine Mesylate Tablet, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Cycloset | Bromocriptine Mesylate Tablet in breastfeeding?