Duloxetine Capsule, Delayed Release while Breastfeeding
What is Duloxetine Capsule, Delayed Release used for?
Duloxetine Capsule, Delayed Release while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?
8.3 Nursing Mothers Risk Summary Duloxetine is present in human milk. In a published study, lactating women who were weaning their infants were given duloxetine. At steady state, the concentration of duloxetine in breast milk was approximately 25% that of maternal plasma. The estimated daily infant dose was approximately 0.14% of the maternal dose. The developmental and health benefits of human milk feeding should be considered along with the mother's clinical need for duloxetine and any potential adverse effects on the milk-fed child from the drug or from the underlying maternal condition. Exercise caution when duloxetine is administered to a nursing woman. Data The disposition of duloxetine was studied in 6 lactating women who were at least 12 weeks postpartum and had elected to wean their infants. The women were given 40 mg of duloxetine twice daily for 3.5 days. The peak concentration measured in breast milk occurred at a median of 3 hours after the dose. The amount of duloxetine in breast milk was approximately 7 microgram/day while on that dose; the estimated daily infant dose was approximately 2 microgram/kg/day. The presence of duloxetine metabolites in breast milk was not examined.
Duloxetine Capsule, Delayed Release Breastfeeding Analsys
Duloxetine while Breastfeeding
SafeCAS Number: 116539-59-4
It is a reuptake-inhibitor of Serotonin and Norepinephrine. Excreted into breast milk in clinically non-significant amount with no side-effects being observed in breastfed infants from treated mothers. Plasma level in those infants was very low or undetectable. Because there is less experience published than with other antidepressants of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity. Galactorrhea has been observed but less frequently than with other antidepressants. Women who use antidepressant medication during pregnancy are in need of more support for breastfeeding since they are at risk for early weaning.
Duloxetine Capsule, Delayed Release Breastfeeding Analsys - 2
Duloxetine while Breastfeeding
CAS Number: 116539-58-3
Little published information is available on the use of duloxetine during breastfeeding; however, the dose in milk is low and serum levels were low in two breastfed infants. An alternate drug that has been better studied may be preferred, especially while nursing a newborn or preterm infant. If duloxetine is required by the mother, it is not a reason to discontinue breastfeeding. Monitor the infant for drowsiness, adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants and when using combinations of psychotropic drugs. Galactorrhea has been reported in women taking duloxetine.
What if I already have used Duloxetine Capsule, Delayed Release?
It is always a good idea to keep your healthcare provider or doctor informed about your drug usage during pregnancy and breastfeeding but if you have not informed your doctor about Duloxetine Capsule, Delayed Release and have used it then do not panic as Duloxetine Capsule, Delayed Release is mostly safe in breastfeeding and should not cause any harm to your baby.
I am nursing mother and my doctor has suggested me to use Duloxetine Capsule, Delayed Release, is it safe?
Definitely, Duloxetine Capsule, Delayed Release is safe in lactation for baby. No wonder your doctor has recommended it.
If I am using Duloxetine Capsule, Delayed Release, will my baby need extra monitoring?
No extra baby monitoring required while mother is using Duloxetine Capsule, Delayed Release
Who can I talk to if I have questions about usage of Duloxetine Capsule, Delayed Release in breastfeeding?
US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week