Glyburide-metformin Hydrochloride Tablet while Breastfeeding

What is Glyburide-metformin Hydrochloride Tablet used for?

What are the risk associated with Glyburide-metformin Hydrochloride Tablet usage while breastfeeding? What precautions shall I take while using it in breastfeeding?

Glyburide while Breastfeeding

CAS Number: 10238-21-8

Sulfonylureas stimulate endogenous insulin secretion. They can cause hypoglycemia. Its pharmacokinetic data (moderately high molecular weight and very high percentage of plasma protein binding) explain the zero or negligible passage into breast milk observed (Serrano 2014, Glatstein 2009, Feig 2007and 2005). Although blood sugar levels were normal in an infant whose mother was taking glibencamide (Feig 2005), one author suggests monitoring for symptoms of hypoglycemia in the infant (Glatstein 2009). List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002). Diet, exercise, and breastfeeding improve blood sugar levels.

Metformin hydrochloride while Breastfeeding

CAS Number: 657-24-9

Oral antidiabetic medication used for treatment of Diabetes Type II, Obesity and Polycystic Ovarian Syndrome (PCOS). Biguanide drugs act by decreasing Neoglycogenesis (new formation of sugar) in the liver. Low risk of Hypoglycemia. Metformin is excreted into breast milk in non-significant amount and without harmful effect on breastfed infants of treated mothers, Obesity is associated with breastfeeding difficulties. In spite of Metformin has beneficial effect on Obesity, this is not true with PCOS because lactation capacity is related to growth of breast tissue during pregnancy which is not improved by the use of Metformin, Oral antidiabetic drugs are not effective for Diabetes Type I. For Diabetes Type II diet, physical exercise and breastfeeding may ameliorate glycemia levels. See remarks on mother's Diabetes Mellitus by consulting specific item.

Glyburide while Breastfeeding

CAS Number: 10238-21-8

Limited data indicate that the levels of glyburide in milk are negligible. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with hypoglycemic agents.[1][2]

Metformin hydrochloride while Breastfeeding

CAS Number: 657-24-9

Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use, so timing of breastfeeding with respect to the administration times is of little benefit. Although the dose in milk is low, metformin is sometimes detectable in low levels in the serum of breastfed infants. One sizeable prospective study found no adverse effects in breastfed infants. Metformin should be used with caution while nursing newborn and premature infants and those with renal impairment.

What should I do if already breastfed my kid after using Glyburide-metformin Hydrochloride Tablet?

I am nursing mother and my doctor has suggested me to use Glyburide-metformin Hydrochloride Tablet, is it safe?

If I am using Glyburide-metformin Hydrochloride Tablet, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Glyburide-metformin Hydrochloride Tablet in breastfeeding?