Topiclear Lemon | Hydroquinone Cream while Breastfeeding

Topiclear Lemon | Hydroquinone Cream while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Hydroquinone while Breastfeeding

CAS Number: 123-31-9

Benzene derivative which is topically used with creams and solutions (2-4%) as a bleaching agent for several skin disorders associated to hyper-pigmentation. In industry it is used as photographic developer. TLV or threshold limit value which means maximum exposure limit for workers is 2 mg / m3 (Flickinger 1976). At latest update relevant published data were not found on excretion into breast milk. It is well absorbed through the skin, both when used as a therapeutic agent (Bucks 1998, Wester 1998, Westerhof 2005, Andersen 2010, Bozzo 2011) or industrial use (Barber 1995, McGregor 2007), however, a significant excretion into breastmilk is not likely for their lack of fat solubility. There is controversy and doubt about a possible mutagenic and carcinogenic effect (Kooyers 2004, FDA 2006, Levitt 2007, Andersen 2010), so it does not seem wise a chronic or continued use while breastfeeding. Do not apply it on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed.Do not apply it over large areas or on long-term treatments to avoid an excessive systemic absorption.

Hydroquinone while Breastfeeding

CAS Number: 123-31-9

Topical hydroquinone has not been studied during breastfeeding. Hydroquinone is not contraindicated during breastfeeding and if hydroquinone is required by the mother, it is not a reason to discontinue breastfeeding. However, some experts feel that long-term use of hydroquinone is difficult to justify in a nursing mother.[1] If hydroquinone is used, ensure that the infant's skin does not come into direct contact with the areas of maternal skin that have been treated and the infant does not ingest the product from the mother's skin.

Octinoxate and Breastfeeding

Octinoxate (Octylmethoxycinnamate) has been detected in human urine, blood and breast milk and is known for moderate risk of skin allergy. Some studies suggest that Octinoxate has estrogen like effects however less than 1% skin penetration has been found in human laboratory studies. As not much study has been done on effects of Octinoxate during breast feeding its recommended to use safe alternatives.

Octyl Methoxycinnamate (OMC) is a frequently used UV-filter in sunscreens and other cosmetics. Octinoxate can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk. The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men. FDA study found blood levels 13 times above cutoff for systemic exposure.

Several studies indicated that OMC acts as an endocrine disruptor due to the ability to interfere with endocrine system at different levels. In humans OMC exposure has minor, but statistically significant effects on the levels of testosterone and estradiol. Moreover, some studies suggested that OMC can interact with the hypothalamo-pituitary-thyroid (HPT) axis.

Moreover, a study of offspring of dams treated with OMC (500�1000 mg/kg/day) showed sex-dependent behavioral changes, namely decreased motor activity in females, but not in males, and improved spatial learning in males, suggesting that OMC can affect neuronal development, however the doses used in these experiments were extremely high, not relevant to possible human exposure.

I already used Topiclear Lemon | Hydroquinone Cream and meanwhile I breastfed my baby should I be concerned?

I am nursing mother and my doctor has suggested me to use Topiclear Lemon | Hydroquinone Cream, is it safe?

If I am using Topiclear Lemon | Hydroquinone Cream, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Topiclear Lemon | Hydroquinone Cream in breastfeeding?