Amiodarone Hydrochloride Injection Breastfeeding

Most health expert recommend six month of exclusive breastfeeding but statics suggest that numbers are not good, almost 95% mothers start breastfeeding but this number drops to 40% in first three month and further it drops to 15% till fifth month. Sometime its due to need of medication usage. Because of these statics its important to provide good information on safety of drugs in breastfeeding so that it can be improved when possible. In this FAQ sheet we will discuss about exposure to Amiodarone Hydrochloride Injection while breastfeeding. We will also discuss about common side effects and warnings associated with Amiodarone Hydrochloride Injection.

What is Amiodarone Hydrochloride Injection used for?


1. INDICATIONS AND USAGE Amiodarone injection is an antiarrhythmic agent indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. (1) Amiodarone injection is indicated for initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to other therapy. Amiodarone also can be used to treat patients with VT/VF for whom oral amiodarone is indicated, but who are unable to take oral medication. During or after treatment with amiodarone, patients may be transferred to oral amiodarone therapy [see Dosage and Administration (2)]. Use amiodarone for acute treatment until the patient's ventricular arrhythmias are stabilized. Most patients will require this therapy for 48 to 96 hours, but amiodarone may be safely administered for longer periods if necessary.

Amiodarone Hydrochloride Injection while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Amiodarone Hydrochloride Injection high risk while breastfeeding
As Amiodarone Hydrochloride Injection is made of only Amiodarone hydrochloride, and Amiodarone hydrochloride is unsafe to use in breastfeeding we can safely reach on conclusion that Amiodarone Hydrochloride Injection is also unsafe to use while breastfeeding. Below is detailed analysis of Amiodarone hydrochloride and Amiodarone Hydrochloride Injection during location. We recommend you to go through provided detailed analysis as below take decision accordingly. We also recommend you talk to your health care provider before making final decision.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Amiodarone and one of its major metabolites, desethylamiodarone (DEA), are excreted in human milk, suggesting that breast-feeding could expose the nursing infant to a significant dose of the drug. Nursing offspring of lactating rats administered amiodarone have demonstrated reduced viability and reduced body weight gains. The risk of exposing the infant to amiodarone must be weighed against the potential benefit of arrhythmia suppression in the mother. Advise the mother to discontinue nursing.

Amiodarone Hydrochloride Injection Breastfeeding Analsys


Amiodarone hydrochloride while Breastfeeding

Unsafe

CAS Number: 1951-25-3

A published case of infant hypothyroidism. Others have reported lab controlled cases with harmless effect in breastfed babies.

Amiodarone Hydrochloride Injection Breastfeeding Analsys - 2


Amiodarone hydrochloride while Breastfeeding

CAS Number: 1951-25-3

Breastmilk and infant serum levels of amiodarone and its active metabolite are somewhat unpredictable, but can be high during breastfeeding. The infant receives an estimated dose of amiodarone plus desethylamiodarone ranging from 3.5 to 45% of the mother's weight-adjusted amiodarone dose, with a median dose of about 11%.[1][2][3][4] Infant serum levels of the drug plus metabolite range from 14 to 74% of simultaneous maternal levels, with the higher values reflecting transplacental passage of the drug.[2][3][4] In addition to possible cardiac effects, these compounds contain a large amount of iodine which may be released during metabolism. Thyroid dysfunction was reported in one breastfed infant. Even if the drug were discontinued at birth, the mother would continue to excrete amiodarone and its metabolite (and possibly large amounts of iodine) into breastmilk for days to weeks. Some investigators believe that breastfeeding can be undertaken during maternal amiodarone use with periodic monitoring of infant cardiac and thyroid function status,[5][6] especially if only a single dose of amiodarone is given.[7] Infant serum levels of amiodarone and desethylamiodarone may be useful for ruling out cardiac effects of the drug. If hypothyroidism develops, therapy should be promptly initiated.

Is Amiodarone Hydrochloride Injection safe while breastfeeding

What should I do if already breastfed my kid after using Amiodarone Hydrochloride Injection?

If you observer abnormal behavior or any other health issue in infant then you should immediately call 911 or contact other contact other emergency service provider in your area otherwise closely monitor the baby and inform your doctor about your Amiodarone Hydrochloride Injection usage and time interval of breastfeeding.


I am nursing mother and my doctor has suggested me to use Amiodarone Hydrochloride Injection, is it safe?

If your doctor knows that you are breastfeeding mother and still prescribes Amiodarone Hydrochloride Injection then there must be good reason for that as Amiodarone Hydrochloride Injection is considered unsafe, It usually happens when doctor finds that overall advantage of taking outweighs the overall risk.


If I am using Amiodarone Hydrochloride Injection, will my baby need extra monitoring?

Yes, Extra monitoring is required if mother is using Amiodarone Hydrochloride Injection and breastfeeding as it is considered unsafe for baby.


Who can I talk to if I have questions about usage of Amiodarone Hydrochloride Injection in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

Drug Brands with same Active ingredients

Pacerone | Amiodarone Hydrochloride Tablet
Amiodarone Hcl | Amiodarone Hydrochloride Tablet
Nexterone | Amiodarone Hydrochloride Injection
Amiodarone Hcl Injection