Most health expert recommend six month of exclusive breastfeeding but statics suggest that numbers are not good, almost 95% mothers start breastfeeding but this number drops to 40% in first three month and further it drops to 15% till fifth month. Sometime its due to need of medication usage. Because of these statics its important to provide good information on safety of drugs in breastfeeding so that it can be improved when possible. In this FAQ sheet we will discuss about exposure to Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution while breastfeeding. We will also discuss about common side effects and warnings associated with Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution.
What is Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution ?
Azacitidine for injection is a nucleoside metabolic inhibitor indicated for the treatment of patients with the following FAB myelodysplastic syndrome (MDS) subtypes: Refractory anemia (RA) or refractory anemia with ringed sideroblasts (RARS) (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMMoL). (1) 1.1 Myelodysplastic Syndromes (MDS) Azacitidine for injection is indicated for treatment of patients with the following French-American-British (FAB) myelodysplastic syndrome subtypes: refractory anemia (RA) or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukemia (CMMoL).
Is using Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution safe or dangerous while breastfeeding?
Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution contains Azacitidine as active ingredients, . We do not have safety rating of Azacitidine but we do have analysis of Azacitidine, which is used in manufacturing of Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution. You can get a good idea about Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution usage while breastfeeding by going through our detailed analysis as below.
Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Females and Males Reproductive Potential Based on its mechanism of action and findings in animals, Azacitidine can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1)]. Pregnancy Testing Verify the pregnancy status of females of reproductive potential prior to initiating azacitidine. Contraception Females Advise females of reproductive potential to avoid pregnancy during treatment with azacitidine. Males Males with female sexual partners of reproductive potential should not father a child and should use effective contraception during treatment with azacitidine. Infertility Based on animal data, azacitidine could have an effect on male or female fertility [see Nonclinical Toxicology (13.1)].
Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution Breastfeeding Analsys
CAS Number: 320-67-2
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy. It might be possible to breastfeed safely during intermittent azacitidine therapy with an appropriate period of breastfeeding abstinence; the manufacturer recommends an abstinence period of 1 week after the last dose. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[1] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[2]

What should I do if already breastfed my kid after using Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution?
We are not completely sure about safety of Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution in breastfeeding. We would suggest you to contact your doctor or health care provider and explain your situation with Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution. If you observe anything abnormal with your baby please call 911 or contact emergency services in your area.
My doctor has prescribed me Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution, what should I do?
If your doctor considers Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution safe enough to prescribe for you that means its benefits outweigh its known risks.
If I am using Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution, will my baby need extra monitoring?
Not Sure, Please check with your doctor or lactation consultant.
Who can I talk to if I have questions about usage of Azacitidine For | Azacitidine Injection, Powder, Lyophilized, For Solution in breastfeeding?
US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday
UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700
Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week
Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week