Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup while Breastfeeding

What is Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup ?

Can I use Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup while breastfeeding?

Brompheniramine maleate while Breastfeeding

CAS Number: 980-71-2

First generation antihistamine, alkylamine drug, sedative with antimuscarinic effect. Described irritability, crying and insomnia in a baby from a nursing mother after taking a preparation compounded by Iso-ephedrine and brompheniramine that were possibly responsible for the symptoms.Check up the occurrence of drowsiness and inappropriate feeding of the infant. Likely inhibition of breastfeeding in the first weeks after birth due to anti-prolactin effect. It is not recommended bed-sharing with the baby if you are on this medication.

Pseudoephedrine hydrochloride while Breastfeeding

CAS Number: 90-82-4

Marketed on multiple compounds as a constituent of antitussives, mucolytics, expectorants and nasal decongestants (Nice 2000).Simple formulations (one active ingredient per drug) are preferable even more while breastfeeding. It is excreted into breast milk in a clinically non-significant amount (Findlay 1984, Kanfer 1993, Nice 2000, Aljazaf 2003) without major problems having been reported in infants whose mothers had received this medication (Ito 1993, Aljazaf 2003, Soasan 2014). Two infants out of ten appeared with mild irritability that did not require medical care (Ito 1993) with only 4 cases related to maternal pseudoephedrine intake having been declared to the French Pharmaceutical Surveillance Database in 26 years (Soasan 2014) . According to one author, it may decrease the milk production, hence a high intake of fluids is recommended to the mother (Nice 2000). Pseudoephedrine produced a variable and non-significant decrease on prolactin levels along with a variable decrease (between 3% and 59%, on average 25%, and a median 15%) on milk production in 8 women whose infants were beyond neonatal period (Aljazaf 2003).Based on the latter single work (Aljazaf 2003), it has been speculated with the use of pseudoephedrine to treat hypergalactia, galactorrhea and to inhibit milk production (Eglash 2014, Trimeloni 2016). Nor-pseudoephedrine was found in the urine of infants whose mothers had consumed a stimulant plant called Catha edulis o cat (Kristiansson 1987). Although not recommended during lactation by some authors (Rubin 1986, Amir 2011), others think it is compatible (Findlay 1984, Ghaeli 1993, Ito 1993, Mitchell 1999, Nice 2000). The American Academy of Pediatrics considers it to be a medication usually compatible with breastfeeding (AAP 2001). It is suggested the use of a lowest effective dose as possible avoiding a long-term use. Monitor milk production, especially if associated with use of Triprolidine (see specific info) during the neonatal period.

Dextromethorphan hydrobromide while Breastfeeding

CAS Number: 125-71-3

Cough suppressant related with morphine and codeine which is lacking of analgesic or sedative properties. Commonly prescribed by pediatricians. On latest update relevant data on breastfeeding was not found. Because reported low toxicity and mild side effect it is considered to be safe while breastfeeding. Frequently associated to caffeine and other products that are usually compatible with breastfeeding. Avoid use of multiple drug and alcohol containing medication.

Brompheniramine maleate while Breastfeeding

CAS Number: 86-22-6

Small, occasional doses of brompheniramine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use may cause effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Single bedtime doses after the last feeding of the day may be adequate for many women and will minimize any effects of the drug. The nonsedating antihistamines are preferred alternatives.

Pseudoephedrine hydrochloride while Breastfeeding

CAS Number: 90-82-4

Although the small amounts of pseudoephedrine in breastmilk are unlikely to harm the nursing infant, it may cause irritability occasionally. A single dose of pseudoephedrine decreases milk production acutely and repeated use seems to interfere with lactation. Mothers with newborns whose lactation is not yet well established or in mothers who are having difficulties producing sufficient milk should not receive pseudoephedrine. A treatment scheme has been reported for mothers with hypergalactia that uses pseudoephedrine to decrease milk supply.[1]

Dextromethorphan hydrobromide while Breastfeeding

CAS Number: 125-71-3

Neither the excretion of dextromethorphan in milk nor its effect on breastfed infants have been studied. It is unlikely that with usual maternal doses amounts in breastmilk would harm the nursing infant, especially in infants over 2 months of age. It is best to avoid the use of products with a high alcohol content while nursing.

What should I do if I am breastfeeding mother and I am already exposed to Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup?

My doctor has prescribed me Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup, what should I do?

If I am using Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Brompheniramine Maleate, Pseudoephedrine Hydrochloride And Dextromethorphan Hydrobromide Syrup in breastfeeding?