Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream while Breastfeeding

There are total 3 active ingredients in Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream which makes it a complicated task to assess the effect of Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream on breastfeeding. Here on drlact after analyzing all 3 ingredients we have reached on conclusion that Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream is unsafe in breastfeeding. Below is our summarized analysis of Octinoxate, Octisalate, Titanium dioxide.

Octinoxate and Breastfeeding

Octinoxate (Octylmethoxycinnamate) has been detected in human urine, blood and breast milk and is known for moderate risk of skin allergy. Some studies suggest that Octinoxate has estrogen like effects however less than 1% skin penetration has been found in human laboratory studies. As not much study has been done on effects of Octinoxate during breast feeding its recommended to use safe alternatives.

Octyl Methoxycinnamate (OMC) is a frequently used UV-filter in sunscreens and other cosmetics. Octinoxate can be systemically absorbed after skin application, being found in the deeper layers of the stratum corneum as well as urine, plasma, and breast milk. The mean maximum plasma concentration detected after application of 2mg/cm2 sunscreen was 7ng/mL in women and 16ng/mL in men. FDA study found blood levels 13 times above cutoff for systemic exposure.

Several studies indicated that OMC acts as an endocrine disruptor due to the ability to interfere with endocrine system at different levels. In humans OMC exposure has minor, but statistically significant effects on the levels of testosterone and estradiol. Moreover, some studies suggested that OMC can interact with the hypothalamo-pituitary-thyroid (HPT) axis.

Moreover, a study of offspring of dams treated with OMC (500�1000 mg/kg/day) showed sex-dependent behavioral changes, namely decreased motor activity in females, but not in males, and improved spatial learning in males, suggesting that OMC can affect neuronal development, however the doses used in these experiments were extremely high, not relevant to possible human exposure.

Octisalate and Breastfeeding

Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters

Octisalate rarely causes allergies in tropical usage. Not much study has been done on effects of topical usage of Octisalate during breast feeding however it is known to penetrate the skin hence it�s better to use other alternatives.

FDA study found blood levels 10 times above cutoff for systemic exposure, skin penetration in lab studies has been observed

Titanium dioxide and Breastfeeding

Not much study has been done on effects of topical usage of Titanium Dioxide during breast feeding but as there is no finding of Titanium Dioxide passing in breast milk its unlikely to cause any health issue for infant.

Some animal studies suggest that maternal exposure to titanium dioxide nanoparticles during pregnancy and lactation alters offspring hippocampal mRNA BAX and Bcl-2 levels, induces apoptosis and decreases neurogenesis. But dosage was significantly higher than daily possible exposure to humans.

I already used Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream and meanwhile I breastfed my baby should I be concerned?

My doctor has prescribed me Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream, what should I do?

If I am using Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Cle Ccc Deep | Titanium Dioxide, Octinoxate, Octisalate Cream in breastfeeding?