Trileptal | Oxcarbazepine Tablet Breastfeeding

Most health expert recommend six month of exclusive breastfeeding but statics suggest that numbers are not good, almost 95% mothers start breastfeeding but this number drops to 40% in first three month and further it drops to 15% till fifth month. Sometime its due to need of medication usage. Because of these statics its important to provide good information on safety of drugs in breastfeeding so that it can be improved when possible. In this FAQ sheet we will discuss about exposure to Trileptal | Oxcarbazepine Tablet while breastfeeding. We will also discuss about common side effects and warnings associated with Trileptal | Oxcarbazepine Tablet.

What is Trileptal | Oxcarbazepine Tablet used for?


Trileptal is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and as monotherapy in the treatment of partial seizures in children aged 4 years and above with epilepsy, and as adjunctive therapy in children aged 2 years and above with partial seizures. Trileptal is an antiepileptic drug indicated for: Adults: - Monotherapy or adjunctive therapy in the treatment of partial seizures Children: - Monotherapy in the treatment of partial seizures in children 4-16 years - Adjunctive therapy in the treatment of partial seizures in children 2-16 years (1)

Trileptal | Oxcarbazepine Tablet while breastfeeding safe or not? Can there be any side effects for infant while using it during breastfeeding?

Trileptal | Oxcarbazepine Tablet safe for breastfeeding
Active ingredient in Trileptal | Oxcarbazepine Tablet is Oxcarbazepine and based on our analysis of Oxcarbazepine it appears that using Trileptal | Oxcarbazepine Tablet is safe in breastfeeding. Below is analysis of Oxcarbazepine while breastfeeding.

Statement of Manufacturer/Labeler about breastfeeding usage
8.3 Nursing Mothers Oxcarbazepine and its active metabolite (MHD) are excreted in human milk. A milk-to-plasma concentration ratio of 0.5 was found for both. Because of the potential for serious adverse reactions to Trileptal in nursing infants, a decision should be made about whether to discontinue nursing or to discontinue the drug in nursing women, taking into account the importance of the drug to the mother.

Trileptal | Oxcarbazepine Tablet Breastfeeding Analsys


Oxcarbazepine while Breastfeeding

Safe

CAS Number: 28721-07-5

Is Trileptal | Oxcarbazepine Tablet safe while breastfeeding

A derivative of carbamazepine with a very similar chemical structure and therapeutic action. It is rapidly and extensively metabolised to licarbazepine (MHD), its active metabolite. It is excreted in breast milk in clinically insignificant amounts (Lutz 2007, Bulau 1988) and no problems have been observed in infants whose mothers have taken it (Lutz 2007, Tomson 2007, Eisenschenk 2006, Gentile 2003, Bulau 1988). Plasma levels in these infants were very low, less than 5% of maternal plasma levels (Öhman 2009, Lutz 2007). Carbamazepine (see specific information) is considered compatible with breastfeeding by the American Academy of Pediatrics (AAP 2001) and thus appears on the list of WHO essential medicines (WHO/UNICEF 2002). Given the proven benefits of breastfeeding and despite the fact that there is a lack of reports on the safety of oxcarbazepine, several expert authors consider it safe to take during breastfeeding (Uguz 2016, Reimers 2014, Davanzo 2013, Bar-Oz 2000). Furthermore, as an integral and important part of the experience of motherhood, the American Academy of Neurology and the American Academy of Pediatrics advise that mothers undergoing anti-epileptic treatment can breastfeed (Pack 2006). Plasma levels of oxcarbazepine and its metabolite MHD decrease slightly during pregnancy and increase significantly in the immediate postpartum period. Therefore, close monitoring of these levels is required to adjust the dosage of the drug (Mazzucchelli 2006) See below the information of these related products:

Trileptal | Oxcarbazepine Tablet Breastfeeding Analsys - 2


Oxcarbazepine while Breastfeeding

CAS Number: 28721-07-5

Limited information indicates that oxcarbazepine would not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. Monitor the infant for drowsiness, adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants and when using combinations of anticonvulsants.


What should I do if already breastfed my kid after using Trileptal | Oxcarbazepine Tablet?

As usage of Trileptal | Oxcarbazepine Tablet is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Trileptal | Oxcarbazepine Tablet else no further action is required.


I am nursing mother and my doctor has suggested me to use Trileptal | Oxcarbazepine Tablet, is it safe?

Usage of Trileptal | Oxcarbazepine Tablet is safe for nursing mothers and baby, No worries.


If I am using Trileptal | Oxcarbazepine Tablet, will my baby need extra monitoring?

No


Who can I talk to if I have questions about usage of Trileptal | Oxcarbazepine Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week

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