Epclusa | Velpatasvir And Sofosbuvir Tablet while Breastfeeding

What is Epclusa | Velpatasvir And Sofosbuvir Tablet used for?

I am currently breastfeeding and I want to know if using Epclusa | Velpatasvir And Sofosbuvir Tablet is safe for my kid? Does it have any effect on milk production?

Velpatasvir while Breastfeeding

CAS Number: 1377049-84-7

Usually used in combination with sofosbuvir in the treatment of hepatitis C. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (high molecular weight and very high percentage of protein binding) make it very unlikely that significant amounts would pass into breast milk, therefore it would not be necessary to stop breastfeeding when taking this medication on its own or in combination with sofosbuvir (Lactmed 2016). See below the information of these related products:

Sofosbuvir while Breastfeeding

CAS Number: 1190307-88-0

Usually used in combination with Ledispavir in the treatment of hepatitis C. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (moderately elevated molecular weight, good percentage of protein binding and very short half-life) impedes its passage to breast milk in significant amounts, so although there is disagreement (Thompson 2016), some authors consider that treatment with sofosbuvir, alone or in combination with ledipasvir is not contraindicated during breastfeeding (Spera 2016). See below the information of these related products:

Velpatasvir while Breastfeeding

CAS Number: 1377049-84-7

Velpatasvir has not been studied in nursing mothers being treated for hepatitis C infection. Because it is greater than 99.5% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If velpatasvir used alone or in combination with sofosbuvir is required by the mother, it is not a reason to discontinue breastfeeding. Some sources recommend against breastfeeding when velpatasvir is used with ribavirin. Hepatitis C is not transmitted through breastmilk[1][2] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[3][4] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[1][2]

Sofosbuvir while Breastfeeding

CAS Number: 1190307-88-0 1620486

Sofosbuvir has not been studied in nursing mothers being treated for hepatitis C infection. If sofosbuvir alone or in combination with ledipasvir (Harvoni) is required by the mother, it is not a reason to discontinue breastfeeding.[1] Some sources recommend against breastfeeding when sofosbuvir is used with ribavirin. Hepatitis C is not transmitted through breastmilk[2][3] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[4][5] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[2][3]

I already used Epclusa | Velpatasvir And Sofosbuvir Tablet and meanwhile I breastfed my baby should I be concerned?

My health care provider has asked me to use Epclusa | Velpatasvir And Sofosbuvir Tablet, what to do?

If I am using Epclusa | Velpatasvir And Sofosbuvir Tablet, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Epclusa | Velpatasvir And Sofosbuvir Tablet in breastfeeding?