Nesina | Alogliptin Tablet Breastfeeding

There are high number of clear evidence that breastfeeding provides best nutrition that you can give to your baby. It is also evident that lactation is good for mothers health as well. Evolution has designed breastfeeding in a way that it caters all nutritional need of your child. However modern medicine is quite new for evolution, that is why mothers body is not well prepared to filter unnecessary chemical found in medicines. It becomes a necessity to figure out which drug is safe and which drug is dangerous for your newborn while nursing. In this article we will understand function of Nesina | Alogliptin Tablet and its suitability with breastfeeding.

What is Nesina | Alogliptin Tablet used for?


NESINA is a dipeptidyl peptidase-4 (DPP-4) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. (1.1, 14) Important Limitations of Use: Not for treatment of type 1 diabetes or diabetic ketoacidosis. (1.1) 1.1 Monotherapy and Combination Therapy NESINA is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [see Clinical Studies (14)]. Important Limitations of Use NESINA is not indicated for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis, as it would not be effective in these settings.

I am breastfeeding mother and I am using Nesina | Alogliptin Tablet. Can it have any bad effect on my kid? Shall I search for better alternative?

Nesina | Alogliptin Tablet low risk for breastfeeding
Alogliptin is the one and only active ingredient present in Nesina | Alogliptin Tablet. Alogliptin in itself is a low risk drug for lactation so it is easy to understand that Nesina | Alogliptin Tablet also comes in category of Low Risk item while breastfeeding. Below is the summary of Alogliptin in breastfeeding.

Nesina | Alogliptin Tablet Breastfeeding Analsys


Alogliptin while Breastfeeding

Low Risk

CAS Number: 850649-61-5

Is Nesina | Alogliptin Tablet safe while breastfeeding

It promotes pancreatic insulin secretion by inhibiting the DPP-4 enzyme that degrades the GLP-1 and GIP intestinal hormones involved in the physiological regulation of glucose, which are activated by eating (EMA 2016, Baetta 2011, Scheen 2011). Administered orally, once a day. Common side effects are upper respiratory tract infections, urinary tract infections, gastrointestinal disorders, rash and headaches (EMA, 2016). Low risk of hypoglycemia in monotherapy (EMA, 2015, Scheen 2011). Doses up to 16 times higher than normal for 2 weeks did not produce side effects (EMA, 2015). Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (EMA 2015, Scheen 2011): low molecular weight, low percentage of binding to plasma proteins and very long half-life) make it likely it will pass into breast milk in concentrations that could be significant. Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity. Diet, exercise, and breastfeeding improve blood sugar levels. Among the antidiabetics of this same group, saxagliptin and vildagliptin would be preferable due to their short half-life (less than 3 hours). See below the information of these related products:

Nesina | Alogliptin Tablet Breastfeeding Analsys - 2


Alogliptin while Breastfeeding

CAS Number: 850649-61-5

No information is available on the clinical use of alogliptin during breastfeeding. If alogliptin is required by the mother, it is not a reason to discontinue breastfeeding. However, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Saxagliptin has a shorter half-life than the other dipeptidyl-peptidase IV inhibitors and linagliptin is highly protein bound, so these might be better choices among drugs in this class for nursing mothers. Monitoring of the breastfed infant's blood glucose is advisable during maternal therapy with alogliptin.[1]

Nesina | Alogliptin Tablet safe for breastfeeding

What should I do if I am breastfeeding mother and I am already exposed to Nesina | Alogliptin Tablet?

Nesina | Alogliptin Tablet is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Nesina | Alogliptin Tablet so you should inform him based on your convenience.


I am nursing mother and my doctor has suggested me to use Nesina | Alogliptin Tablet, is it safe?

Nesina | Alogliptin Tablet comes in category of low risk and if your doctor is aware that you are breastfeeding it should be ok to use without much concerns.


If I am using Nesina | Alogliptin Tablet, will my baby need extra monitoring?

Not much monitoring required while using Nesina | Alogliptin Tablet


Who can I talk to if I have questions about usage of Nesina | Alogliptin Tablet in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week