Azathioprine Sodium Injection, Powder, Lyophilized, For Solution Breastfeeding

It is recommended to breastfeed exclusively for six months and then while introducing to other food sources extend it to twelve months. In this duration most mothers will need help of some sort of medication, It could be for short term like could and flue or it could be something chronic like Arthritis or Diabetes and here comes the question of safety of medication in use. In this post we will figure out what is Azathioprine Sodium Injection, Powder, Lyophilized, For Solution and whether its safe to use Azathioprine Sodium Injection, Powder, Lyophilized, For Solution while nursing or not.

What is Azathioprine Sodium Injection, Powder, Lyophilized, For Solution used for?


Azathioprine Sodium for Injection, USP is indicated as an adjunct for the prevention of rejection in renal homotransplantation. It is also indicated for the management of active rheumatoid arthritis to reduce signs and symptoms. Renal Homotransplantation Azathioprine is indicated as an adjunct for the prevention of rejection in renal homotransplantation. Experience with over 16,000 transplants shows a five-year patient survival of 35% to 55%, but this is dependent on donor, match for HLA antigens, anti-donor or anti-B-cell alloantigen antibody and other variables. The effect of azathioprine on these variables has not been tested in controlled trials. Rheumatoid Arthritis Azathioprine is indicated for the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms. Aspirin, non-steroidal anti-inflammatory drugs and/or low dose glucocorticoids may be continued during treatment with azathioprine. The combined use of azathioprine with disease modifying anti-rheumatic drugs (DMARDs) has not been studied for either added benefit or unexpected adverse effects. The use of azathioprine with these agents cannot be recommended.

Can I continue breastfeeding if I am using Azathioprine Sodium Injection, Powder, Lyophilized, For Solution? How long does it stays in breast milk?

Azathioprine Sodium Injection, Powder, Lyophilized, For Solution safe for breastfeeding
As per our analysis Azathioprine Sodium Injection, Powder, Lyophilized, For Solution contains only one ingredient and that is Azathioprine. We have analyzed Azathioprine and it seems to be safe to use Azathioprine while breastfeeding, that means usage of Azathioprine Sodium Injection, Powder, Lyophilized, For Solution shall be safe while breastfeeding. Below you can check more details of Azathioprine usage in breastfeeding. We recommend you to go through provided detailed analysis as below take decision accordingly.

Statement of Manufacturer/Labeler about breastfeeding usage
Nursing Mothers The use of azathioprine in nursing mothers is not recommended. Azathioprine or its metabolites are transferred at low levels, both transplacentally and in breast milk.8, 9, 10 Because of the potential for tumorigenicity shown for azathioprine, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Azathioprine Sodium Injection, Powder, Lyophilized, For Solution Breastfeeding Analsys


Azathioprine while Breastfeeding

Safe

CAS Number: 446-86-6

Even though it is metabolized to mercaptopurine, just tiny amounts of this drug have been found in breast milk (4 - 18 micrograms/liter). Among several breastfed infants of mothers who were treated with Azathioprine failed to be detected in the blood nor side effects were found. Long-term infectious diseases were not more common among exposed infants. Exposition would be minimized if nursing is resumed 3 hours after last dose.

Azathioprine Sodium Injection, Powder, Lyophilized, For Solution Breastfeeding Analsys - 2


Azathioprine while Breastfeeding

CAS Number: 446-86-6

Is Azathioprine Sodium Injection, Powder, Lyophilized, For Solution safe while breastfeeding

Most experts consider breastfeeding during azathioprine to be acceptable.[1][2][3][4][5][6][7][8] Studies in women with inflammatory bowel disease, systemic lupus erythematosus or transplantation taking doses of azathioprine up to 200 mg daily for immunosuppression have found either low or unmeasurable levels of the active metabolites in milk and infant serum. Some evidence indicates a lack of adverse effects on the health and development of infants exposed to azathioprine during breastfeeding up to 3.5 years of age, but long-term follow-up for effects such as carcinogenesis have not been performed. Mothers with decreased activity of the enzyme that detoxifies azathioprine metabolites may transmit higher levels of drug to their infants in breastmilk. Cases of mild, asymptomatic neutropenia have been reported, so it might be desirable to monitor exclusively breastfed infants with a complete blood count with differential, and liver function tests if azathioprine is used during lactation, although some authors feel that monitoring is unnecessary.[9] Avoiding breastfeeding for 4 hours after a dose should markedly decrease the dose received by the infant in breastmilk.[10]


What if I already have used Azathioprine Sodium Injection, Powder, Lyophilized, For Solution?

As usage of Azathioprine Sodium Injection, Powder, Lyophilized, For Solution is mostly safe while breastfeeding hence there should not be any concern. In case of any change in behavior or health of your baby you should inform your health care provider about usage of Azathioprine Sodium Injection, Powder, Lyophilized, For Solution else no further action is required.


My doctor has prescribed me Azathioprine Sodium Injection, Powder, Lyophilized, For Solution, what should I do?

Usage of Azathioprine Sodium Injection, Powder, Lyophilized, For Solution is safe for nursing mothers and baby, No worries.


If I am using Azathioprine Sodium Injection, Powder, Lyophilized, For Solution, will my baby need extra monitoring?

No


Who can I talk to if I have questions about usage of Azathioprine Sodium Injection, Powder, Lyophilized, For Solution in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week