Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered while Breastfeeding

What is Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered ?

Is using Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered safe or dangerous while breastfeeding?

Fluticasone propionate while Breastfeeding

CAS Number: 90566-53-3

At latest update no relevant data on this subject were found in connection with breastfeeding, however, its low systemic absorption rate with a high plasma protein-binding capacity makes that excretion into breast milk may be very unlikely. Experts on this field consider topical, oral or inhaled steroids compatible with breastfeeding. At usual dose of oral, inhaled (nasal or pulmonary) or dermatologic preparations are used, absorption is very low with non-significant levels achieved in plasma serum. Whenever a treatment for eczema or dermatitis of the nipple is required, the least potent preparation should be used. Apply after a breast feed to let it to disappear before the next feed. Clear out excess of cream with a gauze when indicated. Avoid continuous use for longer than a week. Steroid toxicity has occurred in an infant after continuous use of steroidal cream on the nipple. Avoid use of creams, gels and other topical medication containing paraffin (petroleum-derived mineral oil) in order to avoid the risk of absorption by the child.

Salmeterol while Breastfeeding

CAS Number: 89365-50-4

Long-acting bronchodilator.

 At latest update no published data on excretion into breastmilk were found.

 Because of a high plasma protein-binding capacity and very low or undetectable plasma concentrations observed after inhalation (Cazzola 2002, AEMPS 2012) the excretion into breastmilk in significant amounts is unlikely.
Its low oral bioavailability would hamper the pass to the infant’s plasma through the breastmilk ingested.

 Experts and scientific societies consider the use of Salmeterol during breastfeeding as devoid of risk for the infant (Ellsworth 1994, McDonald 1996, Nelson 2001, National Asthma Education 2004).

 Terbutaline (see specific info), a molecule related to the same group of drugs, is excreted in non-significant amounts into breastmilk.

Fluticasone propionate while Breastfeeding

CAS Number: 90566-53-3

Topical fluticasone has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[1] Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area.

Salmeterol while Breastfeeding

CAS Number: 89365-50-4

Although no published data exist on the use of salmeterol by mouth or inhaler during lactation, data from the related drug, terbutaline, indicate that very little is expected to be excreted into breastmilk.[1] The authors of several reviews agree that use of inhaled bronchodilators is acceptable during breastfeeding because of the low bioavailability and maternal serum levels after use.[2][3][4][5]

I already used Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered and meanwhile I breastfed my baby should I be concerned?

My doctor has prescribed me Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered, what should I do?

If I am using Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered, will my baby need extra monitoring?

Who can I talk to if I have questions about usage of Advair Hfa | Fluticasone Propionate And Salmeterol Xinafoate Aerosol, Metered in breastfeeding?