Lipofen | Fenofibrate Capsule Breastfeeding

For most of the drugs advantages of taking medications overweighs the potential risks however some drugs could be really dangerous for breastfed baby hence every medication shall be considered separately. In this page we will discuss about purpose of Lipofen | Fenofibrate Capsule and its risk associated with lactation. We will also discuss the usage of Lipofen | Fenofibrate Capsule and some common side effects associated with Lipofen | Fenofibrate Capsule.

What is Lipofen | Fenofibrate Capsule used for?


LIPOFEN is a peroxisome proliferator-activated receptor (PPAR) alpha agonist indicated as an adjunct to diet: To reduce elevated LDL-C, total-c, TG and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (1.1) To reduce triglycerides in adult patients with severe hypertriglyceridemia (1.2) Important Limitations of Use: Fenofibrate at a dose equivalent to 150 mg of LIPOFEN was not shown to reduce coronary heart disease morbidity and mortality in a large, randomized controlled trial of patients with type 2 diabetes mellitus (5.1) 1.1 Primary Hypercholesterolemia or Mixed Dyslipidemia LIPOFEN is indicated as adjunctive therapy to diet to reduce elevated low- density lipoprotein cholesterol (LDL-C), total cholesterol (total-c), Triglycerides (TG) and apolopoprotein B (Apo B), and to increase high- density lipoprotein cholesterol (HDL-C) in adult patients with primary hypercholesterolemia or mixed dyslipidemia. 1.2 Severe Hypertriglyceridemia LIPOFEN is also indicated as adjunctive therapy to diet for treatment of adult patients with severe hypertriglyceridemia. Improving glycemic control in diabetic patients showing fasting chylomicronemia will usually obviate the need for pharmacologic intervention. Markedly elevated levels of serum triglycerides (e.g. > 2,000 mg/dL) may increase the risk of developing pancreatitis. The effect of fenofibrate therapy on reducing this risk has not been adequately studied. . 1.3 Important Limitations of Use Fenofibrate at a dose equivalent to 150 mg of LIPOFEN was not shown to reduce coronary heart disease morbidity and mortality in 2 large, randomized controlled trials of patients with type 2 diabetes mellitus [see Warnings and Precautions (5.1)].

I am breastfeeding mother and I am using Lipofen | Fenofibrate Capsule. Can it have any bad effect on my kid? Shall I search for better alternative?

Lipofen | Fenofibrate Capsule low risk for breastfeeding
Lipofen | Fenofibrate Capsule contains only one active ingredient that is Fenofibrate. We have analyzed the usage of Fenofibrate in breastfeeding and our analysis suggest that Fenofibrate poses Low risk for infant while breastfeeding and hence Lipofen | Fenofibrate Capsule itself shall be considered Low risk item for breastfeeding.

Lipofen | Fenofibrate Capsule Breastfeeding Analsys


Fenofibrate while Breastfeeding

Low Risk

CAS Number: 49562-28-9

Is Lipofen | Fenofibrate Capsule safe while breastfeeding

Fenofibrate, like other fibrates, decreases elevated blood lipids (triglycerides and cholesterol) by increasing the activity of lipases that catabolize triglyceride-rich lipoproteins and slightly decreasing cholesterol biosynthesis (AEMPS 2017, BGP 2015, Miller 1998). In general, fibrates have a discrete effect on the increase of high density lipoprotein (HDL) concentration and the reduction of low density lipoprotein (LDL). Since the last update we have not found published data in relation to breastfeeding. Its high binding to plasma proteins makes it unlikely it will pass into breast milk. Cholesterol levels in milk are very stable even in hypercholesterolemic women and are not severely affected by diet or nutritional status of the mother, suggesting that 3 is synthesized, at least in part, in the mammary gland (Lawrence 2016, p 289-90).It is not probable therefore, but it is not known if the fibrates are able to alter the lipid composition of the milk. Infants need to ingest large amounts of cholesterol, as it is critical to the proper development of the nervous system, cell membranes and is a precursor of several hormones and vitamins. Until there is more data in relation to breastfeeding, it is prudent to avoid using it, at least while breastfeeding exclusively. Suspending the pharmacological treatment of hyperlipidemia during breastfeeding is not likely to alter the long-term outcome of the disease, especially when breastfeeding can be considered therapeutic (Lawrence 2016, p.393). It is advisable to follow a lipid-lowering diet. In case of administering a fibrate during breastfeeding it is advisable to choose those with a shorter half-life: bezafibrate, gemfibrozil.

Lipofen | Fenofibrate Capsule Breastfeeding Analsys - 2


Fenofibrate while Breastfeeding

CAS Number: 49562-28-9

No relevant published information exists on the use of fenofibrate during breastfeeding. Because of a concern with disruption of infant lipid metabolism, fenofibrate is best avoided during breastfeeding. An alternate drug is preferred, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be avoided during fenofibrate therapy and for 5 days after the final dose.


What should I do if I am breastfeeding mother and I am already exposed to Lipofen | Fenofibrate Capsule?

Lipofen | Fenofibrate Capsule is in the category of low risk, if you have already used it then its not a big deal if health and behavior of baby is good. However your health care provider shall be aware of the fact that you have used Lipofen | Fenofibrate Capsule so you should inform him based on your convenience.


I am nursing mother and my doctor has suggested me to use Lipofen | Fenofibrate Capsule, is it safe?

Though Lipofen | Fenofibrate Capsule dose not comes in category of safe drugs rather it comes in category of low risk but if your doctor is aware that you are breastfeeding your baby and has still recommended it then its advantages must be outweighing the risks.


If I am using Lipofen | Fenofibrate Capsule, will my baby need extra monitoring?

Not much monitoring required while using Lipofen | Fenofibrate Capsule


Who can I talk to if I have questions about usage of Lipofen | Fenofibrate Capsule in breastfeeding?

US
National Womens Health and Breastfeeding Helpline: 800-994-9662 (TDD 888-220-5446) 9 a.m. and 6 p.m. ET, Monday through Friday

UK
National Breastfeeding Helpline: 0300-100-0212 9.30am to 9.30pm, daily
Association of Breastfeeding Mothers: 0300-330-5453
La Leche League: 0345-120-2918
The Breastfeeding Network supporter line in Bengali and Sylheti: 0300-456-2421
National Childbirth Trust (NCT): 0300-330-0700

Australia
National Breastfeeding Helpline: 1800-686-268 24 hours a day, 7 days a week

Canada
Telehealth Ontario for breastfeeding: 1-866-797-0000 24 hours a day, 7 days a week